Download PDF
Planta Med 1990; 56(3): 271-273
DOI: 10.1055/s-2006-960954
Paper

© Georg Thieme Verlag Stuttgart · New York

Glaucolide B, A Molluscicidal Sesquiterpene Lactone, and Other Constituents of Vernonia eremophila

Maria Cristina B. V. Alarcon1 , João L. Callegari Lopes1 , Werner Herz2
  • 1Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, 14049 Ribeirão Preto, S.P., Brasil
  • 2Department of Chemistry, Florida State University, Tallahassee, Florida 32306, U.S.A.
Further Information

Publication History

1989

Publication Date:
05 January 2007 (online)

Also available at
 PDF Download  Permissions and Reprints

Abstract

The sesquiterpene lactone glaucolide B was isolated from the molluscicidal extract of Vernonia eremophila Mart, and shown to be responsible for the molluscicidal activity. Hydrogenolysis of glaucolide B resulted in the disappearance of the activity. Other inactive constituents of the extract were 3,7-dimethoxy-5,3′,4′-trihydroxyflavone and two transformation products, possibly artefacts, of glaucolide B. Glaucolide B exhibited strong antimicrobial activity against B, cereus and moderate activity against S. aurens, but was inactive in several other systems.

Key words

Vernonia eremophylla - glaucolides - sesquiterpene lactones - molluscicides - flavonoids